Purported spoilers:
[spoil]
[align=left]The spider bite no longer gives Peter powers, it rather activates something already in his genetic structure.
Something placed there by his father.
Peter Parker is no longer super-powered by chance, but rather by design.
Peter no longer goes into wrestling, for one, and that change creates a small ripple effect of other changes - leading up to changes in Uncle Ben's death.
[/align]
[/spoil]
So far this franchise has given us:
- Spider-Man 2:
Raindrops Keep Falling On My Head.
- Spider-Man 3: The Musical
- Spider-Man on Broadway.